Details for The genetics of Non-Alcoholic Fatty Liver Disease: Spotlight on PNPLA3 & TM6SF2

Name:The genetics of Non-Alcoholic Fatty Liver Disease: Spotlight on PNPLA3 & TM6SF2

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum that spans simple steatosis, through non-alcoholic steatohepatitis (NASH) to fibrosis and ultimately cirrhosis. Non-alcoholic fatty liver disease is characterized by substantial inter-patient variation in rate of progression and disease outcome: Although up to 25% of the general population are at risk of progressive disease, only a minority experience associated liver-related morbidity. Non-alcoholic fatty liver disease is considered a complex disease trait that occurs when environmental exposures act upon a susceptible polygenic background composed of multiple independent modifiers. Recent advances include the identification of PNPLA3 as a modifier of disease outcome across the full spectrum of NAFLD from steatosis to advanced fibrosis and hepatocellular carcinoma; and the discovery of TM6SF2 as a potential “master regulator” of metabolic syndrome outcome, determining not only risk of advanced liver disease, but also cardiovascular disease outcomes. In this article, the authors will review the field, discussing in detail the current status of research into these important genetic modifiers of NAFLD progression.

Authors:Anstee, Q.M. & Day, C.P.
Journal Title:Seminars in Liver Disease
Journal Year:2015
Volume / Issue No.:35(03)
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Filesize: 256 Bytes
Filetype:htm (Mime Type: text/html)
Created On: 05/22/2016 10:18
Maintained by:ixscient
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Last updated on: 05/22/2016 10:23
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