Details for PNPLA3 and obesity: a synergistic relationship in NAFLD

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Name:PNPLA3 and obesity: a synergistic relationship in NAFLD
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NAFLD, the hepatic manifestation of the metabolic syndrome, is a multifactorial condition — environmental factors influence an inherited genetic risk. Stender et al. now describe the additive effect of obesity and NAFLD-associated genetic polymorphisms on steatosis, elevated serum alanine aminotransferase levels and cirrhosis, remarkably illustrating the principle of gene–environment interactions.

Refers to Stender, S. et al. Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci. Nat. Genet. 49, 842–847 (2017)

Authors:Mann, J.P. & Anstee, Q.M.
Journal Title:Nature Reviews Gastroenterology & Hepatology
Journal Year:2017
Volume / Issue No.:14
Digital Object Identifier:http://dx.doi.org/10.1038/nrgastro.2017.74
Filename:NoDoc1527413993.htm
Filesize: 256 Bytes
Filetype:htm (Mime Type: text/html)
Creator:ixscient
Created On: 05/27/2018 09:39
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Last updated on: 05/27/2018 09:42
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