Details for MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals

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Name:MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals
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Nonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C > T MBOAT7/TMC4 variant predisposes to progressive NAFLD, but the impact on hepatic carcinogenesis is unknown. In Italian NAFLD patients, the rs641738 T allele was associated with NAFLD-HCC (OR 1.65, 1.08–2.55; n = 765), particularly in those without advanced fibrosis (p < 0.001). The risk T allele was linked to 3’-UTR variation in MBOAT7 and to reduced MBOAT7 expression in patients without severe fibrosis. The number of PNPLA3, TM6SF2, and MBOAT7 risk variants was associated with NAFLD-HCC independently of clinical factors (p < 0.001), but did not significantly improve their predictive accuracy. When combining data from an independent UK NAFLD cohort, in the overall cohort of non-cirrhotic patients (n = 913, 41 with HCC) the T allele remained associated with HCC (OR 2.10, 1.33–3.31). Finally, in a combined cohort of non-cirrhotic patients with chronic hepatitis C or alcoholic liver disease (n = 1121), the T allele was independently associated with HCC risk (OR 1.93, 1.07–3.58). In conclusion, the MBOAT7 rs641738 T allele is associated with reduced MBOAT7 expression and may predispose to HCC in patients without cirrhosis, suggesting it should be evaluated in future prospective studies aimed at stratifying NAFLD-HCC risk.

Authors:Donati, B. et al
Journal Title:Scientific Reports
Journal Year:2017
Volume / Issue No.:7(4492)
Digital Object Identifier:http://dx.doi.org/10.1038/s41598-017-04991-0
Filename:Donati_et_al-2017-Scientific_Reports.pdf
Filesize: 1.44 MB
Filetype:pdf (Mime Type: application/pdf)
Creator:ixscient
Created On: 06/02/2018 20:15
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Last updated on: 06/02/2018 20:18
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