Details for Plasma DNA methylation: A potential biomarker for stratification of liver fibrosis in NAFLD

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Name:Plasma DNA methylation: A potential biomarker for stratification of liver fibrosis in NAFLD
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Liver biopsy is currently the most reliable way of evaluating liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Its inherent risks limit its widespread use. Differential liver DNA methylation of peroxisome proliferator-activated receptor gamma (PPARĪ³) gene promoter has recently been shown to stratify patients in terms of fibrosis severity but requires access to liver tissue. The aim of this study was to assess whether DNA methylation of circulating DNA could be detected in human plasma and potentially used to stratify liver fibrosis severity in patients with NAFLD.

Authors:Hardy, T. et al
Journal Title:Hepatology
Journal Year:2016
Volume / Issue No.:
Digital Object Identifier:http://dx.doi.org/10.1136/gutjnl-2016-311526
Filename:Hardy_Hepatology_2016.pdf
Filesize: 2.77 MB
Filetype:pdf (Mime Type: application/pdf)
Creator:ixscient
Created On: 05/22/2016 10:40
Viewers:Everybody
Maintained by:ixscient
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Last updated on: 09/27/2016 10:31
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