Details for Inflammation induced IgA+ cells dismantle anti-liver cancer immunity

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Name:Inflammation induced IgA+ cells dismantle anti-liver cancer immunity
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The role of adaptive immunity in early cancer development is controversial. Here we show that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver disease is accompanied by accumulation of liver-resident immunoglobulin-A-producing (IgA+) cells. These cells also express programmed death ligand 1 (PD-L1) and interleukin-10, and directly suppress liver cytotoxic CD8+ T lymphocytes, which prevent emergence of hepatocellular carcinoma and express a limited repertoire of T-cell receptors against tumour-associated antigens. Whereas CD8+ T-cell ablation accelerates hepatocellular carcinoma, genetic or pharmacological interference with IgA+ cell generation attenuates liver carcinogenesis and induces cytotoxic T-lymphocyte-mediated regression of established hepatocellular carcinoma. These findings establish the importance of inflammation-induced suppression of cytotoxic CD8+ T-lymphocyte activation as a tumour-promoting mechanism.

Authors:Shalapour, S. et al
Journal Title:Nature
Journal Year:2017
Volume / Issue No.:551
Digital Object Identifier:http://dx.doi.org/10.1038/nature24302
Filename:NoDoc1533663423.htm
Filesize: 256 Bytes
Filetype:htm (Mime Type: text/html)
Creator:ixscient
Created On: 08/07/2018 17:37
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Maintained by:ixscient
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Last updated on: 08/07/2018 17:39
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