Details for Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD

Name:Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD

The term non-alcoholic fatty liver disease (NAFLD) covers a pathologic spectrum from lipid accumulation alone (simple steatosis) to steatosis with associated inflammation and fibrosis (non-alcoholic steatohepatitis [NASH]). Non-alcoholic steatohepatitis can progress to cirrhosis and potentially to hepatocellular carcinoma. Although a genetic predisposition has been highlighted, NAFLD is strongly associated with an unhealthy lifestyle and hypercaloric diet in the context of obesity and metabolic disease. The dysregulation of specific pathways (insulin signalling, mitochondrial function, fatty acid, and lipoprotein metabolism) have been linked to steatosis, but elucidating the molecular events determining evolution of the disease still requires further research before it can be translated into specific personalized interventional strategies. In this review, the authors focus on the early events of the pathophysiology of NASH, dissecting the metabolic and nutritional pathways involving fatty acids and glucose sensors that can modulate lipid accumulation in the liver, but also condition the progression to cirrhosis and hepatocellular carcinoma.

Authors:Vacca, M., Allison, M., Griffin, J.L., Vidal-Puig, A.
Journal Title:Seminars in Liver Disease
Journal Year:2015
Volume / Issue No.:35(03)
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Filename:Vacca_Seminars in Liver Disease 2015 Final.pdf
Filesize: 2.47 MB
Filetype:pdf (Mime Type: application/pdf)
Created On: 10/11/2015 16:19
Maintained by:ixscient
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Last updated on: 11/07/2016 14:12
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