Details for Genetic Factors that Affect Risk of Alcoholic and Non-Alcoholic Fatty Liver Disease

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Name:Genetic Factors that Affect Risk of Alcoholic and Non-Alcoholic Fatty Liver Disease
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Genome-wide association studies and candidate gene studies have informed our understanding of factors contributing to the well-recognized interindividual variation in the progression and outcomes of alcoholic liver disease and nonalcoholic fatty liver disease. We discuss the mounting evidence for shared modifiers and common pathophysiological processes that contribute to development of both diseases. We discuss the functions of proteins encoded by risk variants of genes including patatin-like phospholipase domain-containing 3 and transmembrane 6 superfamily member 2, as well as epigenetic factors that contribute to the pathogenesis of alcoholic liver disease and nonalcoholic fatty liver disease. We also discuss important areas of future genetic research and their potential to affect clinical management of patients.

Authors:Anstee, Q.M., Seth, D. & Day, C.P.
Journal Title:Gastroenterology
Journal Year:2016
Volume / Issue No.:150(8)
Digital Object Identifier:http://dx.doi.org/10.1053/j.gastro.2016.01.037
Filename:NoDoc1488733193.htm
Filesize: 256 Bytes
Filetype:htm (Mime Type: text/html)
Creator:ixscient
Created On: 03/05/2017 16:59
Viewers:Everybody
Maintained by:ixscient
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Last updated on: 03/05/2017 17:05
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