Details for The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of NAFLD

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Name:The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of NAFLD
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We have recently shown in 125 subjects that insulin resistance and the PNPLA3 I148M gene variant, two common risk factors of NAFLD, are characterized with markedly different content and composition of lipids in the human liver. In 2015, a variant in membrane bound O-acyltransferase domain containing 7 (MBOAT7) at rs641738 was discovered to increase the risk of alcohol-related cirrhosis. This variant was also shown to increase the risk of steatosis and histologic liver damage in NAFLD, independent of obesity.

Authors:Luukkonen, P.K. et al
Journal Title:Journal of Hepatology
Journal Year:2016
Volume / Issue No.:65(6)
Digital Object Identifier:http://dx.doi.org/10.1016/j.jhep.2016.07.045
Filename:NoDoc1488989743.htm
Filesize: 256 Bytes
Filetype:htm (Mime Type: text/html)
Creator:ixscient
Created On: 03/08/2017 16:15
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Maintained by:ixscient
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Last updated on: 03/08/2017 16:20
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