Details for Obesity/insulin resistance rather than liver fat increases coagulation factor activities and express

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Name:Obesity/insulin resistance rather than liver fat increases coagulation factor activities and express
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Increased liver fat may be caused by insulin resistance and adipose tissue inflammation or by the common I148M variant in PNPLA3 at rs738409, which lacks both of these features. We hypothesised that obesity/insulin resistance rather than liver fat increases circulating coagulation factor activities. We measured plasma prothrombin time (PT, Owren method), activated partial thromboplastin time (APTT), activities of several coagulation factors, VWF:RCo and fibrinogen, and D-dimer concentration in 92 subjects divided into groups based on insulin sensitivity and PNPLA3 genotype.

We conclude that obesity/insulin resistance rather than an increase in liver fat is associated with a procoagulant plasma profile. This reflects adipose tissue inflammation and increased hepatic production of coagulation factors and their susceptibility for activation.

Authors:Lallukka, S. et al
Journal Title:Thrombosis and Haemostasis
Journal Year:2017
Volume / Issue No.:2017(2)
Digital Object Identifier:http://dx.doi.org/10.1160/TH16-09-0716
Filename:NoDoc1488990228.htm
Filesize: 256 Bytes
Filetype:htm (Mime Type: text/html)
Creator:ixscient
Created On: 03/08/2017 16:23
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Last updated on: 03/08/2017 16:30
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