Details for Genetics of alcoholic liver disease

Name:Genetics of alcoholic liver disease

Excess alcohol consumption with consequent alcoholic liver disease (ALD) is a common cause of liver dysfunction and liver-related mortality worldwide. However, although the majority of heavy drinkers will develop steatosis, only a minority progress to advanced liver disease and cirrhosis. Thus, ALD is a complex disease where subtle inter-patient genetic variations and environmental factors interact to determine disease progression. One genome-wide association study specifically addressing genetic modifiers of ALD has been published. However, most of our understanding is based on studies conducted on nonalcoholic fatty liver disease. Translation of candidates from these studies into ALD has established a role for variants in genes including PNPLA3 and potentially TM6SF2 across the disease spectrum from steatosis, through cirrhosis to hepatocellular carcinoma. Here the authors review the current status of the field with a particular focus on recent advances.

Authors:Anstee, Q.M., Daly, A.K. & Day, C.P.
Journal Title:Seminars in Liver Disease
Journal Year:2015
Volume / Issue No.:35(04)
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Filesize: 256 Bytes
Filetype:htm (Mime Type: text/html)
Created On: 05/22/2016 10:24
Maintained by:ixscient
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Last updated on: 05/22/2016 10:36
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