Details for PNPLA3 and obesity: a synergistic relationship in NAFLD

Name:PNPLA3 and obesity: a synergistic relationship in NAFLD

NAFLD, the hepatic manifestation of the metabolic syndrome, is a multifactorial condition — environmental factors influence an inherited genetic risk. Stender et al. now describe the additive effect of obesity and NAFLD-associated genetic polymorphisms on steatosis, elevated serum alanine aminotransferase levels and cirrhosis, remarkably illustrating the principle of gene–environment interactions.

Refers to Stender, S. et al. Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci. Nat. Genet. 49, 842–847 (2017)

Authors:Mann, J.P. & Anstee, Q.M.
Journal Title:Nature Reviews Gastroenterology & Hepatology
Journal Year:2017
Volume / Issue No.:14
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Created On: 05/27/2018 09:39
Maintained by:ixscient
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Last updated on: 05/27/2018 09:42
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